Stress and Brain Aging: Role of Glucocorticoid and Mineralocorticoid Hormones
| Autor: | Edo R. de Kloet |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.drug_class business.industry Neurotoxicity medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Glucocorticoid receptor Mineralocorticoid medicine Chronic stress business Receptor Neuroscience Brain aging hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Glucocorticoid medicine.drug Hormone |
| DOI: | 10.1016/b978-0-12-809324-5.22064-6 |
| Popis: | Aging is characterized by a decreased ability to adapt. The neurotoxicity/cascade hypothesis highlights causality of adrenal glucocorticoid and mineralocorticoids in acceleration of brain aging during chronic stress. The susceptibility/vulnerability hypothesis depends on (early) stressful life experiences and metabolism that prime brain circuits for coping with future challenges. These actions exerted by the steroids are mediated in complementary fashion by mineralocorticoid receptors (MR) and glucocorticoid receptors (GR). A balanced MR:GR function maintains stability and promotes resilience as a determinant in aging and age-related pathology. |
| Databáze: | OpenAIRE |
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