Base-modified oligodeoxynucleotides. I. effect of 5-alkyl, 5-(1-alkenyl) and 5-(1-alkynyl) substitution of the pyrimidines on duplex stability and hydrophobicity

Autor:	László Ötvös, Janos Sagi, Eva Ruff, Gyula Sági, Attila Szemzo, Katalin Ebinger, Anna Szabolcs
Rok vydání:	1993
Předmět:	chemistry.chemical_classification Stereochemistry Chemistry Oligonucleotide Organic Chemistry Desoxyribonucleotide Biochemistry Deoxyribonucleotide chemistry.chemical_compound Duplex (building) Drug Discovery Moiety Chemical stability Solubility Alkyl
Zdroj:	Tetrahedron Letters. 34:2191-2194
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)60379-9
Popis:	Properties of oligodeoxynucleotides essential for the antisense effect can be favourably modified by substitution of the heterocyclic base moiety. This is shown here for duplex stability by 5 alkyl, 5-(1-alkenyl) and 5-(1-alkynyl) substitution of the pyrimidines in the self-complementary (dT-dA) 10 and (dC-dG) 6 oligomers as well as for the hydrophobic character of the (dT-dA) 10 series.
Databáze:	OpenAIRE
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