ChemInform Abstract: The 'Aqueous' Prins Cyclization: A Diastereoselective Synthesis of 4-Hydroxytetrahydropyran Derivatives

Autor:	Gunda G. K. S. Narayana Kumar, Basi V. Subba Reddy, S. Aravind, Jhillu S. Yadav
Rok vydání:	2008
Předmět:	chemistry.chemical_compound Heteropoly acid Aqueous solution Chemistry Phosphomolybdic acid Organic chemistry General Medicine Prins reaction Environmentally friendly
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200823127
Popis:	Phosphomolybdic acid (H 3 PMo 12 O 40 , a heteropoly acid) is found to catalyze efficiently the Prins cyclization of homoallylic alcohols with aldehydes in water at room temperature to provide tetrahydropyran-4-ol derivatives in high yields with all CIS-selectivity. Only cyclic ketones can give spirocyclic products. The use of phosphomolybdic acid in water makes this procedure simple, more convenient, cost-effective, and environmentally friendly.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::afc276403a971cd0178b28e350a4564f https://doi.org/10.1002/chin.200823127 Zobrazit plný text záznamu Plný text