Bacterial Conjugated Linoleic Acid Effect on Hepatic and Adipose Tis-sues of High-Fat diet-Induced Obese Rats
Autor: | Hasnia Ziar, Mohamed Benali, Imene Yahla, Ali Riazi |
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Rok vydání: | 2016 |
Předmět: |
medicine.medical_specialty
medicine.diagnostic_test Linoleic acid Conjugated linoleic acid Adipose tissue Lipid metabolism Biology medicine.disease biology.organism_classification law.invention Probiotic chemistry.chemical_compound Endocrinology chemistry law Internal medicine medicine Steatosis Lipid profile Bifidobacterium |
Zdroj: | South Asian Journal of Experimental Biology. 6:143-149 |
ISSN: | 2230-9799 |
DOI: | 10.38150/sajeb.6(4).p143-149 |
Popis: | The aim of the present study is to background the effect of conjugated lino-leic acid isomers (CLA) produced by two probiotic strains, Lactobacillus rham-nosus LBRE-LSAS (a human originated bacterium) and Bifidobacterium ani-malis subsp lactis Bb12, on both hepatic and adipose tissues of high-fat diet fed Wistar rats. Five-week-old male Wistar rats were divided into 4 groups (n=6) fed a high-fat diet for three of them (control and supplemented with 1x109 CFU per rat of LBRE-LSAS or Bb12 strain and 1.4% of free linoleic acid; designed as treated rats) and a standard diet for the fourth group. After 8 weeks of experimental period, rats were sacrificed after chloroform anesthe-sia; livers and adipose tissues of each group were excised for biochemical and histological analyses. Obtained results showed that livers of treated high-fat diet fed rats did not exhibit a hepatic steatosis like those of untreated high-fat diet fed rats (control group) did. Lipid profile (triglycerides and total cholesterol) of the liver and the adipose tissue was markedly improved in treated rat groups, especially in LBRE-LSAS strain given high-fat diet rats. Such results strongly support the occurrence of the bacterial power of Lacto-bacillus rhamnosus LBRE-LSAS and Bifidobacterium animalis subsp lactis Bb12 to modulate lipid metabolism and to avoid steatosis in diet-induced model of obesity in rat. |
Databáze: | OpenAIRE |
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