Significance of the multifunctional protein C system research in the treatment of patients with indirect anticoagulants (literature review)
| Autor: | V. V. Egorova, A. A. Zvyagin, V. S. Demidova |
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| Rok vydání: | 2022 |
| Zdroj: | Wounds and wound infections. The prof. B.M. Kostyuchenok journal. 9:12-18 |
| ISSN: | 2500-0594 2408-9613 |
| DOI: | 10.25199/2408-9613-2022-9-1-12-18 |
| Popis: | The multifunctional protein C system regulates both hemostasis and the immune system in response to vascular and inflammatory damage, inhibits thrombinogenesis at an early stage of clotting. A decrease in protein C levels in clinical practice may be associated with vitamin K deficiency, as well as with coumarin therapy. Prolonged use of indirect anticoagulants may be accompanied by a decrease in protein C levels and contribute to the development of rebound thrombosis and thromboembolism. The depth of violations of the protein C system indicates the activation of the microthrombosis process and may affect the outcome of treatment of surgical patients. |
| Databáze: | OpenAIRE |
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