| Autor: |
Rajesh Pamanji, Royya Naresh Kumar, P. Nagender, Loka Reddy Velatooru, Gannarapu Malla Reddy, Janapala Venkateswara Rao, Anugu Chandrashekar Reddy, Banda Narsaiah |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Letters in Drug Design & Discovery. 10:865-871 |
| ISSN: |
1570-1808 |
| Popis: |
The 2-amino-6-trifluoromethyl-3H-pyrimidin-4-one 1 was propargylated to give two regioisomers 2, 3 in defi- nite proportions. Both regioisomers 2 and 3 were independently reacted with alkyl, aryl or cycloalkyl substituted azides under Sharpless conditions and were obtained exclusively 1,4-disubstituted triazole tagged trifluoromethyl substituted pyrimidine derivatives 4 and 5 respectively. All the final products were evaluated for cytotoxic activity against four can- cer cell lines and promising compounds were identified. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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