Comparative study of antioxidant status in women of different age groups with type-2 diabetes
| Autor: | Mikashinovich Zi, T. D. Kovalenko, Olempieva Ev, Ishonina Og |
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| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Antioxidant medicine.medical_treatment Type 2 Diabetes Mellitus Type 2 diabetes Glutathione medicine.disease medicine.disease_cause Lipid peroxidation chemistry.chemical_compound Endocrinology chemistry Internal medicine Diabetes mellitus medicine Geriatrics and Gerontology Gerontology Oxidative stress Polyunsaturated fatty acid |
| Zdroj: | Advances in Gerontology. 2:257-260 |
| ISSN: | 2079-0589 2079-0570 |
| DOI: | 10.1134/s2079057012030058 |
| Popis: | The purpose of this study was to evaluate the metabolic processes in women of different age groups with type-2 diabetes. It was found that hyperglycemia in aging women is characterized by the development of pronounced oxidative stress. The depletion of reduced glutathione pool is associated with a high risk of genotoxicity, since it correlates with the activation of mitochondrial and chromatin dysfunction, as well as with DNA fragmentation. In addition, polyunsaturated fatty acid hydroperoxide formation leads to necrosis and apoptosis. It can be assumed that type-2 diabetes mellitus triggers the process of apoptosis, which leads to the activation of aging programs and an increase in the mortality of patients. It is obvious that the change in the concentration of thiol antioxidants, as well as the change in concentration of molecular products of lipid peroxidation can a criterion for evaluating aging and the efficiency of the treatment of patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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