Effects of Short-Term Treatment with Recombinant Human Growth Hormone on Carbamazepine Pharmacokinetics in Rats
| Autor: | William R Ravis, Yann-Huei Phillip Lee, Yuh-Jing Lin |
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| Rok vydání: | 2013 |
| Předmět: |
Volume of distribution
medicine.medical_specialty business.industry Urinary system Human growth hormone Carbamazepine Pharmacology law.invention Growth hormone treatment Endocrinology Pharmacokinetics law Jugular vein Internal medicine Recombinant DNA General Earth and Planetary Sciences Medicine business General Environmental Science medicine.drug |
| Zdroj: | Clinical & Experimental Pharmacology. |
| ISSN: | 2161-1459 |
| DOI: | 10.4172/2161-1459.1000132 |
| Popis: | Objectives: To investigate the pharmacokinetics of Carbamazepine (CBZ) in rats during growth hormone treatment. Methods: Recombinant Human Growth Hormone (rhGH) was injected subcutaneously at a daily dose of 0.1 mg/ kg, 2 mg/kg, or phosphate buffered saline (control) for 5 days in male Sprague-Dawley rats. On day 6, a dose of 25 mg/kg of CBZ was injected intravenously via a jugular vein cannula into the rat. Growth rate were compared between treatment groups. The pharmacokinetics of CBZ was determined from its concentrations in rats’ blood and urinary samples. Results: Over the 5-day treatment period, growth rate were greater than control for the 2 mg/kg rhGH dosed group. The volume of distribution (Vss) was significantly (p |
| Databáze: | OpenAIRE |
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