Gas antisolvent fractionation based optical resolution of ibuprofen with enantiopure phenylglycinol
| Autor: | László Lőrincz, O. Kéri, E. Varga, János Madarász, Edit Székely, Á. Tóth, L. Kondor |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Chromatography
Supercritical carbon dioxide Resolution (mass spectrometry) Process Chemistry and Technology 02 engineering and technology Fractionation 010402 general chemistry 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Enantiopure drug 020401 chemical engineering chemistry Carbon dioxide Chemical Engineering (miscellaneous) Methanol 0204 chemical engineering Enantiomer Selectivity Waste Management and Disposal |
| Zdroj: | Journal of CO2 Utilization. 27:493-499 |
| ISSN: | 2212-9820 |
| DOI: | 10.1016/j.jcou.2018.09.004 |
| Popis: | Optical resolution is still the dominant route to obtaining enantiopure active ingredients. The traditional methods require large organic solvent quantities and long processing times. Antisolvent fractionation with supercritical carbon dioxide offers intensified processing by drastically reducing the time requirement of the diastereomeric salt precipitation. A novel optical resolution of ibuprofen was developed and optimized with phenylglycinol as a resolving agent and gas antisolvent fractionation as the separation method. Above the critical values of certain operational parameters (carbon dioxide to methanol ratio, apparent diastereomeric salt concentration, equilibration time, the relative volume of the extracting fluid) the selectivity was roughly constant, the optical resolution is robust. The scalemic mixtures were purified by repeated resolution and enantiomeric purities above 99% were reached in three consecutive steps. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect