Protective effect of caffeine and curcumin versus silymarin on nonalcoholic steatohepatitis in rats
| Autor: | Mohamad–Hesham Y Daba, Abd El-Hamid Gaber, Ghada A Hegazy, Nanis S Holah, Esam EL-Din Ibrahim S. Radwan, Abd Elrahman A. Yassin, Fatma El-Desoky |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Materials Science (miscellaneous) Insulin medicine.medical_treatment Chronic liver disease medicine.disease medicine.disease_cause Pathogenesis chemistry.chemical_compound Endocrinology Insulin resistance chemistry Internal medicine Nonalcoholic fatty liver disease Curcumin medicine Caffeine business Oxidative stress |
| Zdroj: | Menoufia Medical Journal. 33:196 |
| ISSN: | 1110-2098 |
| DOI: | 10.4103/mmj.mmj_253_18 |
| Popis: | Objective To compare between the effect of curcumin, caffeine with silymarin on an animal model of nonalcoholic steatohepatitis induced by a high-fat and high-sucrose (HFHS) diet. Background Nonalcoholic fatty liver disease is recognized as the most common cause of chronic liver disease. Pro-inflammatory and anti-inflammatory cytokines play a part in the pathogenesis of nonalcoholic fatty liver disease, oxidative stress, and insulin resistance. Materials and methods Fifty male albino rats were divided into five groups: control group; group B receives a HFHS diet for 16 weeks; group C receives a HFHS diet for 16 weeks and was treated by silymarin in the last 8 weeks; group D receives a HFHS diet for 16 weeks and was treated with curcumin in the last 8 weeks; and group E receives a HFHS diet for 16 weeks and was treated with caffeine in the last 8 weeks. Results The HFHS group shows a significant increase in body weight, insulin, tumor necrosis factor α, malonaldehyde, total cholesterol, and triglycerides; compared with the control group, silymarin-treated, curcumin-treated, and caffeine-treated groups show a significant decrease in these parameters. Conclusion Silymarin-treated, curcumin-treated, and caffeine-treated groups show a significant protection against HFHS (western) diet-induced nonalcoholic steatohepatitis. |
| Databáze: | OpenAIRE |
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