Hybrid nanosilicas produced by the Stöber sol-gel process: In vitro evaluation in MRC-5 cells
| Autor: | Dinara Jaqueline Moura, Eduarda Arndt, Franciele Faccio Busatto, Yolice Patricia Moreno Ruiz, Ana Cristina Borba da Cunha, João Vitor de Oliveira, João Henrique Zimnoch dos Santos, Jussânia Gnoatto |
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| Rok vydání: | 2020 |
| Předmět: |
010302 applied physics
Nanoparticle 02 engineering and technology Polyethylene glycol 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Electronic Optical and Magnetic Materials Nanomaterials chemistry.chemical_compound chemistry Chemical engineering Dynamic light scattering Zwitterion 0103 physical sciences PEG ratio Materials Chemistry Ceramics and Composites Surface modification 0210 nano-technology Sol-gel |
| Zdroj: | Journal of Non-Crystalline Solids. 542:120152 |
| ISSN: | 0022-3093 |
| Popis: | A series of 12 organosilanes exhibiting different steric and electronic properties were employed in the synthesis of hybrid silicas by the Stober sol-gel process. The resulting materials were characterized by a set of complementary techniques (nitrogen adsorption, dynamic light scattering, small-angle X-ray scattering, transmission electron microscopy, and carbon content analysis).. Hybrid silicas bearing polyethylene glycol (PEG), zwitterion (ZWT), and methyl (C1) moieties improved the physical-chemical properties of the nanoparticles for biological applications. Toxicological safety tests were performed on the fibroblast cell line (MRC-5), which showed that the functionalization of silica nanoparticles with PEG and ZWT increased cell viability, 111 ± 8.5% and 114 ± 6.3%, respectively, when compared to that of nanomaterials without functionalization, 98 ± 8.8%. Both functionalized and non-functionalized silica nanoparticles did not cause any damage to the DNA of the cells, even at the highest doses. |
| Databáze: | OpenAIRE |
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