Infertility and celiac disease: do we need more than one serological marker?
| Autor: | Raanan Shamir, Hussein Shamaly, Asher Sharony, Ahmad Mahameed |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Immunoglobulin A
Infertility medicine.medical_specialty education.field_of_study biology Anemia business.industry Population Obstetrics and Gynecology General Medicine medicine.disease Gastroenterology Coeliac disease Serology Internal medicine Immunology medicine biology.protein education business Mass screening Unexplained infertility |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica. 83:1184-1188 |
| ISSN: | 0001-6349 |
| DOI: | 10.1111/j.0001-6349.2004.00592.x |
| Popis: | Objectives. Celiac disease (CD) prevalence is higher in women with infertility. Our study aims were to evaluate the prevalence of undiagnosed CD in Arab infertile women and to explore the usefulness of using more than one serological marker in the diagnostic screening for CD in this population. Methods. Women with unexplained infertility ( n = 192) and age-matched healthy controls ( n = 210) were prospectively enrolled. Serum was tested for human tissue transglutaminase antibodies (TTG), antiendomysial antibodies (EMA), and immunoglobulin A. Intestinal biopsy was offered to women with positive serology or immunoglobulin A (IgA) deficiency. Results. CD was diagnosed in five infertile women (2.65%) and in one control (0.5%) ( p = 0.11). Gastrointestinal complaints were present in 60% (three of five) of women with CD and 11.8% (22 of 187) of women without CD ( p = 0.017). Anemia was reported in 80% of infertile women with CD and 4.8% of infertile women without CD ( p = 0.0001). Conclusions. Undiagnosed CD is... |
| Databáze: | OpenAIRE |
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