Use of radiation therapy in posttransplant lymphoproliferative disorder (PTLD) after liver transplantation
| Autor: | C. Howell, J. Colonna, M. Heyman, B.H. Koffman, A.S. Kennedy |
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| Rok vydání: | 2000 |
| Předmět: |
Porta hepatis
Cancer Research medicine.medical_specialty business.industry medicine.medical_treatment Cancer Immunosuppression Liver transplantation medicine.disease Surgery Lesion Radiation therapy medicine.anatomical_structure Oncology medicine Radiology medicine.symptom Complication Radiation treatment planning business |
| Zdroj: | International Journal of Cancer. 90:104-109 |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/(sici)1097-0215(20000420)90:2<104::aid-ijc6>3.0.co;2-0 |
| Popis: | Posttransplant lymphoproliferative disorder (PTLD) is a common and life-threatening complication of immunosuppression used to prevent rejection of solid organ and bone marrow transplants. There is no standardized treatment algorithm, but numerous management strategies are available. We describe a patient who developed a solitary lymphoproliferative lesion in the porta hepatis 9 months after orthotopic liver transplant. Following reduction in immunosuppression with no response, she was treated with involved field radiotherapy utilizing CT-based treatment planning. A partial radiographic response was obtained, and she has not developed disease in the engrafted liver or systemically. Based on the present case report, involved field radiotherapy seems to be a reasonable treatment option for patients with localized PTLD. Int. J. Cancer (Radiat. Oncol. Invest.) 90:104–109, 2000. © 2000 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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