Suppression of Neutrophil Superoxide Production by Conventional Peritoneal Dialysis Solution
| Autor: | Ing Bl, D K Gupta, Nawab Zm, Daugirdas Jt, Zhou Fq, Rahman Ma |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Chemistry
Manufacturing process Superoxide medicine.medical_treatment 030232 urology & nephrology Biomedical Engineering Medicine (miscellaneous) Bioengineering General Medicine 030204 cardiovascular system & hematology Sterilization (microbiology) Pharmacology Caramelization Peritoneal dialysis Biomaterials 03 medical and health sciences Dialysis solutions chemistry.chemical_compound 0302 clinical medicine medicine |
| Zdroj: | The International Journal of Artificial Organs. 11:351-354 |
| ISSN: | 1724-6040 0391-3988 |
| DOI: | 10.1177/039139888801100508 |
| Popis: | The pH of conventional peritoneal dialysis solution is normally in the range of 5.0 to 5.5, because acid has been added during the manufacturing process to prevent caramelization of dextrose during sterilization. We studied the effects of normalizing the pH of conventional peritoneal dialysis solution on superoxide production by normal human neutrophils. At a pH of 6.0, superoxide generation was 4.07±2.56 (SD) nanomoles per million cells. With normalization of pH to 7.4, superoxide production was 19.3± 7.3 (p < 0.001). The results suggest that the unphysiologic acidity of conventional peritoneal dialysis solution has deleterious consequences on neutrophil superoxide formation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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