Homogeneous catalysts for selective molecular oxygen driven oxidative decarboxylations

Autor:	Willie J. Rivers, Dennis P. Riley, Donald Lee Fields
Rok vydání:	1991
Předmět:	Aqueous solution Decarboxylation Chemistry Iminodiacetic acid Inorganic chemistry Substrate (chemistry) General Chemistry Alkylation Biochemistry Combinatorial chemistry Catalysis chemistry.chemical_compound Colloid and Surface Chemistry Moiety Reactivity (chemistry)
Zdroj:	Journal of the American Chemical Society. 113:3371-3378
ISSN:	1520-5126 0002-7863
DOI:	10.1021/ja00009a023
Popis:	Cobalt (II) ion has been found to catalyze the molecular oxygen driven oxidation of N-(phosphonomethyl)iminodiacetic acid (PMIDA) to N-(phosphonomethyl) glycine (PMG) in aqueous solution. This homogeneous catalytic conversion is novel and represents, in effect, an oxidative dealkylation of one carboxymethyl moiety yielding the N-substituted glycine. The reaction is selective to the desired product PMG when carried out at the natural pH of the free acid substrate (∼1-2) and when carried out at substrate loadings less than 5% by weight. In addition, the catalytic system is selective for the PMIDA substrate; i.e., other closely related ligands show no reactivity, e.g., NTA, EDTA, etc. The results of kinetic and mechanistic studies on dilute systems are presented and discussed with special emphasis on how an understanding of the mechanism can make it possible to generate a catalyst system that gives high yields even with high substrate loadings
Databáze:	OpenAIRE
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