Synthesis of unsaturated lactone moieties by asymmetric hetero Diels–Alder reactions with binaphthol-titanium complexes

Autor:	Markus Kalesse, Ulhas Bhatt, Monika Quitschalle, Mathias Christmann
Rok vydání:	2001
Předmět:	chemistry.chemical_classification Chemistry Stereochemistry Organic Chemistry chemistry.chemical_element Biological activity Biochemistry chemistry.chemical_compound Callystatin A Drug Discovery Diels alder Moiety Organic chemistry Lactone Titanium
Zdroj:	Tetrahedron Letters. 42:1263-1265
ISSN:	0040-4039
Popis:	Natural products like ratjadone and callystatin A contain an α,β-unsaturated lactone moiety which adds to the biological activity of these compounds. Here we report a rapid and practical access to lactone precursor 3 by an asymmetric hetero Diels–Alder reaction as the key step and its subsequent transformation into a suitable building block 4.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::af65f625b12118a11786e137d24abf04 https://doi.org/10.1016/s0040-4039(00)02213-9 Zobrazit plný text záznamu Full Text from ScienceDirect