Combinatorial synthesis of isoxazole library and their liquid crystalline properties

Autor:	Kanji Kubo, Masahiro Tanaka, Akira Mori, Takeharu Haino, Keiko Ideta, Yoshimasa Fukazawa
Rok vydání:	2007
Předmět:	Nitrile Bilayer Organic Chemistry Triple bond Biochemistry chemistry.chemical_compound Crystallography chemistry Phase (matter) Drug Discovery Monolayer Molecule Isoxazole Single crystal
Zdroj:	Tetrahedron. 63:652-665
ISSN:	0040-4020
Popis:	Six types of isoxazoles including 60 molecules were synthesized using combinatorial synthesis on solid support in a parallel fashion. Highly regioselective 1,3-dipolar cycloaddition of the nitrile oxides to the triple bond of the solid-attached ethynylbenzamides gave isoxazoles on solid support in good yield. Thirty molecules of them exhibited mesomorphic properties. The combination of molecular mechanics calculations and X-ray diffraction experiments of 2g and 3g revealed that the smectic phase of 2g had a bilayer structure, whereas 3g showed a monolayer liquid crystalline phase. These are supported in comparison with the single crystal structures of 2g and 3g.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::af635925d4489c2714310434803bf6df https://doi.org/10.1016/j.tet.2006.11.005 Zobrazit plný text záznamu Full Text from ScienceDirect