The Effects of Insulin-Like Growth Factor-1 on Plasminogen Activator Inhibitor-1 Synthesis and Secretion: Results from In Vitro and In Vivo Studies

Autor:	S Orme, P. E. Belchetz, P D Zenobi, Peter J. Grant, M. H. Stickland, S J Padayatty
Rok vydání:	1993
Předmět:	medicine.medical_specialty T-plasminogen activator medicine.medical_treatment Insulin Hematology Biology Hep G2 Insulin-like growth factor chemistry.chemical_compound Cytokine Endocrinology chemistry Internal medicine Plasminogen activator inhibitor-1 Fibrinolysis medicine Plasminogen activator
Zdroj:	Thrombosis and Haemostasis. 70:1009-1013
ISSN:	2567-689X 0340-6245
DOI:	10.1055/s-0038-1649716
Popis:	SummaryIn vitro studies have shown that insulin and IGF-1 releases the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1) from cells of hepatic origin. To investigate the effects of IGF-1 on fibrinolysis: 1) cultured hepatoma cells were grown in the presence of IGF-1 and media collected for secreted PAI-1 and cells probed for PAI-1 mRNA, 2) 8 hypopituitary patients were treated with recombinant human growth hormone (rhGH) and 3) 5 type 2 diabetic patients were treated with recombinant human IGF-1 (rhIGF-1). Treatment of Hep G2 cells with IGF-1 (1000 ng/ml) increased secretion of PAI-1 from a median value of 80 ng/106 cells (range 21-91) to 144 ng/106 cells (range 128-169) after 24 h (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::af625d615573dc5ac54c7bdbf5ad524c https://doi.org/10.1055/s-0038-1649716 Zobrazit plný text záznamu