Bronchoalveolar lavage versus bolus administration of lucinactant, a synthetic surfactant in meconium aspiration in newborn lambs
| Autor: | Xabier Murgia, Francisco J. Alvarez-Diaz, E Ruiz-del-Yerro, Elena Gastiasoro, Hector Lafuente, Carmen Rey-Santano, Victoria E. Mielgo, A Valls-i-Soler |
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| Rok vydání: | 2011 |
| Předmět: |
Pulmonary and Respiratory Medicine
Mechanical ventilation Lung medicine.diagnostic_test business.industry medicine.medical_treatment Lucinactant medicine.disease Pulmonary hypertension Bronchoalveolar lavage Bolus (medicine) medicine.anatomical_structure Meconium Anesthesia Pediatrics Perinatology and Child Health medicine Meconium aspiration syndrome business |
| Zdroj: | Pediatric Pulmonology. 46:991-999 |
| ISSN: | 8755-6863 |
| DOI: | 10.1002/ppul.21460 |
| Popis: | This study was designed to study effects of lung lavage versus the classical bolus instillation with a peptide-based synthetic surfactant (lucinactant) in a model of Meconium Aspiration Syndrome (MAS). Eighteen newborn lambs received meconium and were randomized to: the experimental meconium installation (eMAS) group—lambs with eMAS kept on conventional mechanical ventilation (control); the SF-Bolus group—eMAS receiving a lucinactant bolus (30 mg/ml); or the D-SF-Lavage group—eMAS treated with dilute lucinactant bronchoalveolar lavage (10 mg/ml). Systemic and pulmonary arterial pressures, blood gases, and pulmonary mechanics were recorded for 180 min. In addition, the intrapulmonary distribution of the lucinactant was determined using dye-labeled microspheres. Following meconium instillation, severe hypoxia, hypercapnia, acidosis, and pulmonary hypertension developed, and dynamic compliance decreased (50% from baseline). After lung lavage with dilute lucinactant, gas exchange significantly improved versus bolus instillation (P |
| Databáze: | OpenAIRE |
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