Microwave mediated hydrogen deuterium exchange: a rapid synthesis of 2H-substituted benzimidazole
| Autor: | Srirajan Vaidyanathan, Bruce W. Surber |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
inorganic chemicals
Reaction conditions Benzimidazole Chemistry Organic Chemistry Radiochemistry technology industry and agriculture Oxide Biochemistry Chloride chemistry.chemical_compound Deuterium Drug Discovery Microwave irradiation medicine lipids (amino acids peptides and proteins) Hydrogen–deuterium exchange Microwave medicine.drug |
| Zdroj: | Tetrahedron Letters. 46:5195-5197 |
| ISSN: | 0040-4039 |
| Popis: | Deuterium aromatic substituted compounds were prepared by microwave irradiation of the parent unlabeled compounds in the presence of deuterium oxide and deuterium chloride. The percentage of deuterium incorporation was investigated under various reaction conditions. A rapid synthesis of 2H-substituted benzimidazole under microwave irradiation is described. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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