Unified Approach to Pyrazole-Fused Heterocyclic and Carbocyclic Motifs through One-Pot Condensation and Intramolecular Dipolar Cycloaddition Reaction

Autor:	K. Vijay L. Divya, A. Meena, T. D. Suja
Rok vydání:	2016
Předmět:	010405 organic chemistry Stereochemistry Organic Chemistry Condensation Pyrazole 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis Cycloaddition 0104 chemical sciences chemistry.chemical_compound chemistry Intramolecular force Diazo Cyclopentane
Zdroj:	Synthesis. 48:4207-4212
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0035-1562533
Popis:	A one-pot synthesis of highly substituted pyrazoles that are fused to dihydrochromenes, dihydroquinolines and cyclopentane motifs, from readily available precursors is reported. The reaction involves conversion of alkyne-tethered aldehydes into the corresponding tosylhydrazones, base-mediated generation of diazo compounds, and subsequent intramolecular dipolar cycloaddition reaction. A range of internal and terminal alkynes as well as bromoalkyne compounds can be employed as the tethered dipolarophile to afford the corresponding cycloadducts.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::af4d270b6cee5f241f5cbc253d96ca87 https://doi.org/10.1055/s-0035-1562533 Zobrazit plný text záznamu