Effect of amiridine on conditioned reflex in rats with damaged hippocampus

Autor:	T. A. Mering, Yu. V. Burov, I. V. Viktorov, E. N. Kuleshova
Rok vydání:	1997
Předmět:	business.industry Conditioned reflex Hippocampus Stimulation General Medicine Degeneration (medical) Hippocampal formation General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound chemistry Male rats Medicine business Neuroscience Quinolinic acid
Zdroj:	Bulletin of Experimental Biology and Medicine. 123:147-150
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf02766437
Popis:	It is shown that even after partial damage to the hippocampus in male rats by quinolinic acid, which causes selective degeneration of hippocampal neurons, their conditioned reflex to time remains impaired for a period of several months. Treatment with amiridine improves the learning of time-interval estimation by such rats and promotes compensatory/restorative processes in the brain. The brain contains a great diversity of connections, and their stimulation may offer an opportunity for enhancing the operation of compensatory/restorative mechanisms in it.
Databáze:	OpenAIRE
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