| Autor: |
H. Leppikangas, Jyrki Tenhunen, Leena Lindgren, J.-P. Salenius, Esko Ruokonen |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
Acta Anaesthesiologica Scandinavica. 52:785-792 |
| ISSN: |
0001-5172 |
| DOI: |
10.1111/j.1399-6576.2008.01659.x |
| Popis: |
Background: Levosimendan has a dual mechanism of action: it improves myocardial contractility and causes vasodilatation without increasing myocardial oxygen demand. In a laboratory setting, it selectively increases gastric mucosal oxygenation in particular and splanchnic perfusion in general. The aim of our study was to describe the effects of levosimendan on systemic and splanchnic circulation during and after abdominal aortic surgery. Methods: Twenty abdominal aortic aneurysm surgery patients were randomized to receive either levosimendan (n=10) or placebo (n=10) in a double-blinded manner. Both the mode of anaesthesia and the surgical procedures were performed according to the local guidelines. Automatic gas tonometry was used to measure the gastric mucosal partial pressure of carbon dioxide. Systemic indocyanine green clearance plasma disappearance rate (ICG-PDR) was used to estimate the total splanchnic blood flow. Results: The immediate post-operative recovery was uneventful in the two groups with a comparable, overnight length of stay in the intensive care unit. Cumulative doses of additional vasoactive drugs were comparable between the groups, with a tendency towards a higher cumulative dose of noradrenaline in the levosimendan group. After aortic clamping, the cardiac index was higher [4(3.8–4.7) l/min/m2 vs. 2.6(2.3–3.6) l/min/m2; P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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