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Objective: The aim of this study was to determine whether oak root extract has protective role on burn injuries by using quantitative and histopathological approaches. Material and method: The study was conducted on 16 adult Sprague-Dawley rats aged 8 weeks (weighing 350 g). The rats were assigned into 2 groups including: group 1 consisting of rats employed as controls and group 2 in which rats received oak root extract. After shaving dorsum of rats, second degree burn injury was created at the right and left sides of the line representing vertebral column in both groups. Wound care was provided by using normal saline in group 1, while it was provided by using oat root extract in group 2. The right side was used for macroscopic evaluations, while left side was used for histopathological examination through biopsy samples obtained on the days 1, 3, 7 and 17. On the day 17, the rats were sacrificed under ketamine anesthesia. Cutaneous tissue samples were taken and macroscopic measurements were made by using a grid paper. Edema, neovascularization, inflammatory cell infiltration and re-epithelization were assessed on the histopathological examination. Results: When compared to the control group, it was seen that the extent of burn area was reduced and that degree of neovascularization, inflammatory cell infiltration and re-epithelization was increased with decreased edema was (p |
