Preparation and characterization of controlled heparin release waterborne polyurethane coating systems
| Autor: | Hong Tan, Yunlong Gao, Zhicheng Pan, Jiehua Li, Yuanqing Song, Yi Zhang, Jianshu Li, Qiang Fu, Kunjie Wang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Polymers and Plastics Biocompatibility General Chemical Engineering 02 engineering and technology Thrombin time 010402 general chemistry 01 natural sciences Contact angle chemistry.chemical_compound Polymer chemistry medicine Polyurethane medicine.diagnostic_test Organic Chemistry technology industry and agriculture Heparin 021001 nanoscience & nanotechnology Controlled release 0104 chemical sciences chemistry Chemical engineering Attenuated total reflection 0210 nano-technology Protein adsorption medicine.drug |
| Zdroj: | Chinese Journal of Polymer Science. 34:679-687 |
| ISSN: | 1439-6203 0256-7679 |
| DOI: | 10.1007/s10118-016-1787-3 |
| Popis: | In this study, to improve hemocompatibility of biomedical materials, a waterborne polyurethane (WPU)/heparin release coating system (WPU/heparin) is fabricated via simply blending biodegradable WPU emulsions with heparin aqueous solutions. The surface compositions and hydrophilicity of these WPU/heparin blend coatings are characterized by attenuated total reflectance infrared spectroscopy (ATR-FTIR) and water contact angle measurements. These WPU/heparin blend coatings show effectively controlled release of heparin, as determined by the toluidine blue method. Furthermore, the biocompatibility and anticoagulant activity of these blend coatings are evaluated based on the protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT), thrombin time (TT), hemolysis, and cytotoxicity. The results indicate that better hemocompatibility and cytocompatilibity are obtained due to blending heparin into this waterborne polyurethane. Thus, the WPU/heparin blend coating system is expected to be valuable for various biomedical applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink