Organocatalytic enantioselective synthesis of β-blockers: (S)-propranolol and (S)-naftopidil

Autor:	Sharad P. Panchgalle, Uttam R. Kalkote, Subhash P. Chavan, Rohitkumar G. Gore
Rok vydání:	2009
Předmět:	Inorganic Chemistry chemistry.chemical_classification chemistry Naftopidil Stereochemistry Organic Chemistry medicine Enantioselective synthesis Propranolol Physical and Theoretical Chemistry Aldehyde Catalysis medicine.drug
Zdroj:	Tetrahedron: Asymmetry. 20:1767-1770
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2009.07.002
Popis:	An efficient enantioselective synthesis of β-adrenergic blockers (S)-propranolol and (S)-naftopidil with >98% ee using an l -proline-catalyzed α-aminoxylation of an aldehyde as a key step is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::af3e694d20561453e6d93878d8e48fdd https://doi.org/10.1016/j.tetasy.2009.07.002 Zobrazit plný text záznamu Full Text from ScienceDirect