Autor:	A. Yu. Misharin, D. V. Ignatov, N. V. Medvedeva, O. M. Ipatova, Yu. I. Prokof'ev, Vladimir P. Timofeev
Rok vydání:	2003
Předmět:	chemistry.chemical_compound Chemistry Silica gel organic chemicals Organic Chemistry Bioorganic chemistry Organic chemistry Biochemistry Alkaline hydrolysis Terpenoid
Zdroj:	Russian Journal of Bioorganic Chemistry. 29:390-394
ISSN:	1068-1620
DOI:	10.1023/a:1024961503987
Popis:	Treatment of 18β-glycyrrhizic acid with a methanolic solution of HCl resulted in 1 : 1 mixture of methyl esters of 18α- and 18β-glycyrrhetinic acids. Benzoylation of the mixture led to methyl esters of 3-benzoyl-18α-glycyrrhetinic acid and 3-benzoyl-18β-glycyrrhetinic acid, which were separated by chromatography on silica gel. 18α-Glycyrrhetinic acid was prepared by alkaline hydrolysis of methyl 3-benzoyl-18α-glycyrrhetinate and was further used for the syntheses of 3-keto-18α-glycyrrhetinic acid and methyl esters of 18α-glycyrrhetinic acid and 3-keto-18α-glycyrrhetinic acid.
Databáze:	OpenAIRE
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