In situ mantle cell lymphoma in the nasopharynx
| Autor: | Georgios Karkavelas, Fani Tsiompanou, Ioannis Kostopoulos, Sevasti Ouzounidou, Triantafyllia Koletsa, Konstantinos Markou |
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| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty music.instrument medicine.diagnostic_test business.industry Mantle zone medicine.disease Follicular hyperplasia Lymphoid hyperplasia Lymphoma Cyclin D1 Otorhinolaryngology immune system diseases hemic and lymphatic diseases Biopsy medicine Mantle cell lymphoma CD5 medicine.symptom music business |
| Zdroj: | Head & Neck. 35:E333-E337 |
| ISSN: | 1043-3074 |
| DOI: | 10.1002/hed.23206 |
| Popis: | Background Mantle cell lymphoma (MCL) is a B-cell neoplasm with an aggressive clinical course. Recently, an indolent type of MCL has been described under the term in situ MCL. Methods and Results We report a case of a 70-year-old woman who presented with nasal obstruction. A mass, located in the nasopharynx, was found. Histologic examination revealed lymphoid hyperplasia characterized by CD5 and cyclin D1–positive mantle zone cells, findings consistent with in situ MCL. Three years later, a new biopsy was performed, which showed the same histologic and immunohistochemical (IHC) findings to those observed in the first biopsy. The diagnosis of in situ MCL was confirmed by fluorescence in situ hybridization (FISH) analysis for t(11;14). Since then, the patient has remained free of an overt lymphoma. Conclusions In situ MCL may be observed in the nasopharynx, and it would be appropriate to perform cyclin D1 immunostain in cases with marked follicular hyperplasia accompanied by clinical suspicion of lymphoma. © 2012 Wiley Periodicals, Inc. Head Neck, 35: E333–E337, 2013 |
| Databáze: | OpenAIRE |
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