Antimicrobial activities of mycoleptodiscin B isolated from endophytic fungus Mycoleptodiscus sp. of Calamus thwaitesii Becc
| Autor: | Ravi L. C. Wijesundera, Pamoda B. Ratnaweera, Ranga K. Dissanayake, David E. Williams, E. Dilip de Silva, Raymond J. Andersen, C. Dilrukshi Wijayarathne |
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| Rok vydání: | 2016 |
| Předmět: |
0106 biological sciences
biology Traditional medicine 010405 organic chemistry Medicine (miscellaneous) Bacillus subtilis Pathogenic fungus biology.organism_classification medicine.disease_cause Antimicrobial Isolation (microbiology) 01 natural sciences Methicillin-resistant Staphylococcus aureus Plant use of endophytic fungi in defense 0104 chemical sciences Staphylococcus aureus Botany medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Candida albicans 010606 plant biology & botany |
| Zdroj: | Journal of Applied Pharmaceutical Science. :001-006 |
| ISSN: | 2231-3354 |
| DOI: | 10.7324/japs.2016.600101 |
| Popis: | Endophytic fungi are a promising source of novel biologically active compounds including antimicrobials. Plant endophytic fungi of Sri Lanka, an island with exceptionally high biodiversity and endemism, are a vastly untapped resource. Therefore this study was initiated with the objective of examining the antimicrobial producing potential of the endophytic fungi of Calamus thwaitesii Becc. from Sri Lanka. This examination resulted in the isolation of 21 fungi with 7 of them exhibiting antimicrobial properties. Further investigation of the Mycoleptodiscus sp. isolated from the leaves, which showed the best activity among them, resulted in the isolation of the known alkaloid mycoleptodiscin B and its structure was elucidated and confirmed by mass and nuclear magnetic resonance spectral data. Mycoleptodiscin B showed promising antimicrobial activity against Bacillus subtilis (MIC 0.5 µg mL-1) and Staphylococcus aureus (MIC 1 µg mL-1), and was less potent against methicillin resistant Staphylococcus aureus (MRSA, MIC 32 µg mL-1) and the pathogenic fungus Candida albicans (MIC 64 µg mL-1). This is the first study to report the isolation, identification and antimicrobial properties of endophytic fungi of C. thwaitesii and the antimicrobial activities of the alkaloid mycoleptodiscin B. |
| Databáze: | OpenAIRE |
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