A convenient synthesis of [11C]paraquat and other [N-methyl-11C]bisquaternary ammonium compounds
| Autor: | Douglas M. Jewett, Michael R. Kilbourn |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
chemistry.chemical_classification
Methyl triflate Organic Chemistry Salt (chemistry) Biochemistry Chemical synthesis Analytical Chemistry chemistry.chemical_compound Chelex 100 Paraquat chemistry Drug Discovery Organic chemistry Radiology Nuclear Medicine and imaging Chelation Bisquaternary ammonium compounds Ion-exchange resin Spectroscopy |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 45:281-289 |
| ISSN: | 1099-1344 0362-4803 |
| DOI: | 10.1002/jlcr.564 |
| Popis: | [11C]Paraquat was synthesized by the reaction of [11C]methyl triflate with the mono-triflate salt of 1-methyl-[4,4′]bipyridinyl. The product was selectively separated from the precursor by a microcolumn of Chelex 100 ion exchange resin. The method was applied to the synthesis of a variety of [N-methyl-11C]bisquaternary ammonium compounds. This is the first reported use of a chelating cation exchange resin for the selective purification of organic dications. Copyright © 2002 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text