Chitosan/chondroitin sulfate aerogels with high polymeric electroneutralization degree: formation and mechanical properties
| Autor: | Miguel Concha, Judit G. Lisoni, Carla Henríquez-Báez, Luis Morán-Trujillo, Carlos Morales, Alejandra Vidal, Sandra L. Orellana, Annesi Giacaman, Felipe Oyarzun-Ampuero, Ignacio Moreno-Villoslada |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Chemistry General Chemical Engineering 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Polysaccharide Biocompatible material 01 natural sciences 0104 chemical sciences Degree (temperature) Chitosan chemistry.chemical_compound Chemical engineering Chondroitin sulfate 0210 nano-technology |
| Zdroj: | Pure and Applied Chemistry. 90:901-911 |
| ISSN: | 1365-3075 0033-4545 |
| DOI: | 10.1515/pac-2016-1111 |
| Popis: | The formation of ultralight, highly porous solid materials (porosity higher than 99%) containing equivalent molar amounts of chitosan (CS) and chondroitin sulfate (ChS) is presented. First, we show protocols to produce colloidal suspensions of assembled polymer nanocomplexes by simultaneously mixing equimolar amounts of the oppositely charged polysaccharides, preventing macroprecipitation. The colloidal suspensions were then freeze-dried to form the active aerogels. Apparent density in the order of 100–101 mg/cm3 was achieved. The materials show low stiffness (Young’s modulus of about 2 kPa), which make them easy to handle for clinical applications, and easy to compress, pack, store and transport. These characteristics promote them as cheap, safe and biodegradable materials able to be used for several therapeutic purposes, such as wound healing. |
| Databáze: | OpenAIRE |
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