ABCB1 and SLCO1B1 gene polymorphisms predict methotrexate-resistant for low-risk gestational trophoblastic neoplasia
| Autor: | Manasawee Srisuttayasathien, Ruangsak Lertkhachonsuk, Nutthada Areepium |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pharmacology medicine.medical_specialty biology business.industry Single-nucleotide polymorphism General Medicine Gastroenterology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Polymorphism (computer science) 030220 oncology & carcinogenesis Internal medicine Toxicity biology.protein Molecular Medicine Medicine Biomarker (medicine) Methotrexate Gestational trophoblastic neoplasia business SLCO1B1 Gene medicine.drug |
| Zdroj: | Personalized Medicine. 18:107-114 |
| ISSN: | 1744-828X 1741-0541 |
| Popis: | Aim: The aim of this study was to explore the effects of ABCB1 and SLCO1B1 gene polymorphisms and the methotrexate (MTX) treatment response in patients with low-risk gestational trophoblastic neoplasia (GTN). Materials & methods: Low-risk GTN patients who received MTX as a first-line single agent were enrolled. DNA was extracted from peripheral blood samples from 18 patients and assessed for ABCB1 C3435T and SLCO1B1 T521C. Results: ABCB1 C3435T and SLCO1B1 T521C polymorphisms were not associated with the MTX response or toxicity in Thai patients Conclusion: The selected ABCB1 and SLCO1B1 polymorphism do not predict the risk of MTX resistance in low-risk GTN. |
| Databáze: | OpenAIRE |
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