Management of Cardiopulmonary Bypass-Associated Coagulopathy
| Autor: | Anne E. Cossu, Scott G. Walker, Rania K. Abbasi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Surgical repair
Antifibrinolytic business.industry medicine.drug_class Hypothermia Fibrinogen medicine.disease law.invention surgical procedures operative Coagulation law Hemostasis Anesthesia medicine Cardiopulmonary bypass Coagulopathy medicine.symptom business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Pediatric Critical Care ISBN: 9783319964980 |
| Popis: | Coagulopathy in pediatric patients after cardiopulmonary bypass (CPB) is highly complex and multifactorial. Pediatric patients are at risk for post-CPB coagulopathy due to hemodilution resulting from the CPB circuit, use of varying degrees of hypothermia during surgical procedures, prolonged duration of highly complex surgical repairs, and abnormalities of the immature and cyanotic hematologic system. Hemostasis can be optimized at various stages from the preoperative to postoperative phases. Strategies include intraoperative antifibrinolytic therapy, CPB circuit properties and management, and post-CPB procoagulant therapy. Point-of-care whole-blood assays can be used to more directly guide correction of coagulopathy, utilizing both allogeneic blood products and biosynthetic coagulation factors such as fibrinogen concentrate and prothrombin protein concentrates. This chapter will focus on current controversies surrounding CPB-associated coagulopathy and its management. |
| Databáze: | OpenAIRE |
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