Optimization of a biocatalytic process to gain (R)-1-phenylethanol by applying the software tool Sabento for ecological assessment during the early stages of development

Autor:	Tobias Brinkmann, Stephanie Friedrich, Glenn Gröbe, Martin Kluge, Martin Hofrichter, Katrin Scheibner
Rok vydání:	2014
Předmět:	Process development Chemistry business.industry Process (engineering) Process Chemistry and Technology Software tool Bioengineering Nanotechnology Ecological assessment Biochemistry Catalysis Biotechnological process Software Unspecific peroxygenase Fine chemical Biochemical engineering business
Zdroj:	Journal of Molecular Catalysis B: Enzymatic. 103:36-40
ISSN:	1381-1177
Popis:	Ecological assessment using the software tool Sabento was conducted to compare different processes to gain the fine chemical (R)-1-phenylethanol from ethylbenzene. The software was applied during the biocatalytic process development using the unspecific peroxygenase (EC 1.11.2.1) of the fungus Agrocybe aegerita. The process could be systematically improved with respect to the ecological performance during process development. Compared to a modern chemical process and a further biotechnological process, it now reaches the best environmental key indicator. The software tool Sabento proved to be well suited to work out the most important factors determining the ecological burdens in the early stages of process development.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::af0722246a415302417d30cdc54abd68 https://doi.org/10.1016/j.molcatb.2013.10.002 Zobrazit plný text záznamu Full Text from ScienceDirect