Fast atom bombardment positive-ion mass spectra of 1,2,2-tris(sulfonyl)hydrazines

Autor:	Giuseppe Giordano, Alan C. Sartorelli, Krishnamurthy Shyam, Walter J. McMurray
Rok vydání:	1992
Předmět:	chemistry.chemical_classification Sulfonyl Stereochemistry Substituent Protonation Fast atom bombardment Mass spectrometry Biochemistry Medicinal chemistry chemistry.chemical_compound chemistry Mass spectrum Molecular Medicine Molecule Instrumentation Spectroscopy Alkyl
Zdroj:	Organic Mass Spectrometry. 27:633-635
ISSN:	1096-9888 0030-493X
DOI:	10.1002/oms.1210270518
Popis:	Several 1,2,2-tris(sulfonyl)hydrazines, conceived as prodrugs of 1,2-bis(sulfonyl)hydrazines and synthesized as potential antineoplastic and trypanocidal drugs, were analyzed by mass Spectrometry as part of the confirmation of the structure of these compounds. Since these compounds showed activity against several transplanted animal tumors, an understanding of the mass spectral behavior of these agents is important to gain information should clinical trials and metabolic studies be undertaken. In all spectra, protonated molecular ions were observed. Collision activation resulted in considerable fragmentation in the fast atom bombardment spectra. Rearrangement ions formed by elimination of substituted diimides from the middle of the molecule were observed. Other rearrangements involving the alkyl substituent and sulfonyl oxygen also occurred.
Databáze:	OpenAIRE
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