Clinical Assessment of New Topical Cream Containing Two Essential Oils Combined with Tretinoin in the Treatment of Acne
| Autor: | Elisabetta Gavini, Stefania Anna Lucia Zanetti, Matthew Gavino Donadu, Gabriella Piu, M.A. Montesu, Federica Sucato, Donatella Usai, Valeria Pomponi, Giovanna Rassu, Vittorio Mazzarello |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Transepidermal water loss Erythema business.industry medicine.drug_class Antibiotics Dermatology medicine.disease medicine.disease_cause 030207 dermatology & venereal diseases 03 medical and health sciences Topical cream 0302 clinical medicine In vivo Tretinoin 030220 oncology & carcinogenesis medicine medicine.symptom Irritation business Acne medicine.drug |
| Zdroj: | Clinical, Cosmetic and Investigational Dermatology. 13:233-239 |
| ISSN: | 1178-7015 |
| Popis: | Background Acne is a frequent adolescent disease characterized by inflammatory and non-inflammatory lesions whose topical treatment very often presents adverse phenomena such as irritation or resistance to antibiotics that reduce the patient's compliance. The purpose of this study is to compare a commercial product (Acnatac gel) based on clindamycin-tretinoin (CTG) with a galenic compound containing 2 essential oils (Myrtus communisL. and Origanum vulgare) and tretinoin (MOTC) to evaluate its anti-acne effectiveness and action on the microclimate of the skin. Methods Sixty volunteers were randomly divided into an A group using MOTC and a B group, as a positive control, using CTG. The effectiveness was assessed with non-invasive skin analysis (Sebumeter, pH meter, Tewameter and Mexameter) and the counts of the number of lesions, after 15 and 30 days. Results In both groups, there is a worsening of transepidermal water loss (TEWL) due to tretinoin. MOTC has improved, starting from 15 days of treatment, the papular erythema (p = 0.0329 vs CTG) and has reduced at all times even the rashes of retinoids present in the healthy perilesional skin (p = 0.0329 and p = 0.0017, respectively, at 15 and 30 days). Conclusion MOTC has shown, compared to Acnatac, to have anti-acne efficacy and to possess an anti-inflammatory activity, due to essential oils, able to reduce in vivo erythematous lesions and those induced by retinoids. |
| Databáze: | OpenAIRE |
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