The macroscopic appearance of colorectal polyps

Autor: John Jones Thompson, Horatio T. Enterline
Rok vydání: 1981
Předmět:
Zdroj: Cancer. 48:151-160
ISSN: 1097-0142
0008-543X
Popis: The macroscopic (10 to 30 times magnification) surface features of 187 colonic lesions are described. The lesions were studied using a dissecting microscope and a 1% trypan blue solution as a contrast agent. Using five criteria, lesions were evaluated for the presence or absence of adenoma, the type of adenoma present, the presence of dysplasia or carcinoma-in-situ, and the presence of invasive carcinoma. The technique has proven to be a rapid, sensitive, and relatively specific means of separating tumors in the adenoma—carcinoma sequence from nonadenomatous lesions (sensitivity, 99%, specificity 90%). The technique is accurate in differentiating tubular, tubulovillous, and villous lesions. It is suggested that areas of dysplasia (sensitivity 100%, specificity 93%), carcinoma-in-situ, and microinvasive carcinoma may also be differentiated, but need further investigation. The present study suggests that the macroscopic architecture of the various lesions in the adenoma—carcinoma sequence is unique and may be used diagnostically. These preliminary findings need to be confirmed in a prospective double-blind study, and to be adapted to use in colonoscopic and radiologic diagnosis.
Databáze: OpenAIRE
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