Effect of atypical antipsychotics on antioxidant enzyme activities in human erythrocytes (in vitrostudy)
| Autor: | Vesna Niketić, Aleksandra Nikolić-Kokić, Mihajlo B. Spasić, Dusica Lecic-Tosevski, Čedo Miljević, Duško Blagojević, Milan Nikolić |
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| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
biology medicine.drug_class Glutathione peroxidase Glutathione reductase Atypical antipsychotic Pharmacology 030227 psychiatry 3. Good health 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Neurology Sertindole chemistry Catalase Quetiapine Fumarate biology.protein medicine Quetiapine Pharmacology (medical) Aripiprazole Neurology (clinical) 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Human Psychopharmacology: Clinical and Experimental. 28:1-6 |
| ISSN: | 0885-6222 |
| Popis: | Objective This study was set out to examine the impact of atypical antipsychotic drugs: aripiprazole, clozapine, ziprasidone, olanzapine, quetiapine, sertindole and amisulpride on the activity of antioxidant defence enzymes in human erythrocytes in vitro. Methods Cu,Zn-superoxide dismutase (SOD1), catalase (CAT), selenium-dependent glutathione peroxidase and glutathione reductase activities were determined after drugs incubation with blood of 15 apparently healthy non-smoking male volunteers (ages 23–39) for 1h at 37 � C. Results A statistically significant increase in SOD1 activity was found in samples incubated with aripiprazole (p |
| Databáze: | OpenAIRE |
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