Failure of DHEA to modulate ovariectomy induced osteopenia in rats

Autor:	R. R. Hardin, Richard Cockerham, Dike N. Kalu
Rok vydání:	1983
Předmět:	Aging medicine.medical_specialty Anabolism business.industry Dehydroepiandrosterone General Medicine medicine.disease Ovarian hormone Osteopenia Endocrinology Femoral diaphysis Calcitonin Internal medicine Ovariectomized rat medicine Sprague dawley rats Geriatrics and Gerontology business
Zdroj:	AGE. 6:114-120
ISSN:	1574-4647 0161-9152
DOI:	10.1007/bf02432199
Popis:	As a result of reports indicating that dehydroepiandrosterone (DHEA) has bone anabolic properties, studies were carried out to determine whether DHEA will prevent osteopenia due to ovarian hormone deficiency. Female Sprague Dawley rats were randomized into four groups: Group 1 rats were ovariectomized; Group 2 rats were sham-operated upon; and Group 3 rats were ovariectomized and given subcutaneous injections of DHEA five times per week. Groups 1 and 2 rats were injected similar volume of solvent vehicle, and Group 4 rats were killed at the beginning of the study to serve as baseline controls. Six months after ovariectomy, Groups 1, 2 and 3 rats were bled, killed and their femurs dissected out.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aedd32f6dc569a1a29ad7a432533a5a8 https://doi.org/10.1007/bf02432199 Zobrazit plný text záznamu Full text from SpringerLink