Ultrastructural detection of environmental nanoparticles in circulating blood
| Autor: | Visani, Giuseppe, Manti, Anita, Valentini, Laura, Canonico, Barbara, Loscocco, Federica, Isidori, Alessandro, Gabucci, Elisa, Gobbi, Pietro, Montanari, Stefano, Rocchi, Marco, Papa, Stefano, Gatti, Antonietta M. |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| DOI: | 10.13128/ijae-21742 |
| Popis: | The increase in the incidence of acute myeloid leukemia (AML) may suggest a possible environmental etiology. PM2.5 was declared by the International Agency for Research on Cancer (WHO organ) a Class I carcinogen. To date, no reports have focused on particulate environmental pollution together with AML. The study investigated the presence and composition of particulate matter in circulating blood with a Environmental Scanning Electron Microscope coupled with an Energy Dispersive Spectroscope for the elemental analysis of the samples. 38 peripheral blood samples, 19 AML cases and 19 healthy controls, were analysed. A significant overload of particulate matter-derived nanoparticles linked or aggregated to blood components was found in AML patients, while almost absent in matched healthy controls. Two tailed Student’s t-test, MANOVA and Principal Component Analysis indicated that the total numbers of aggregates and particles were statistically different between cases and controls (MANOVA, P Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016 |
| Databáze: | OpenAIRE |
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