Synthesis and calcium antagonistic activity of diethyl styrylbenzylphosphonates

Autor:	J Tisne-Versailles, G. Tchani, R Bonnafous, S Younes, Genevieve Baziard-Mouysset, Marc Payard, Jean-Luc Stigliani
Rok vydání:	1994
Předmět:	Pharmacology Fostedil Ester derivatives Organic Chemistry Antagonist chemistry.chemical_element Biological activity General Medicine Calcium In vitro chemistry.chemical_compound chemistry Drug Discovery Fluorine Organic chemistry Antagonism
Zdroj:	European Journal of Medicinal Chemistry. 29:87-93
ISSN:	0223-5234
DOI:	10.1016/0223-5234(94)90204-6
Popis:	Twenty-three new phosphonic ester derivatives of stilbene exhibiting structural analogies with fostedil are described. Examination of calcium antagonism showed that this activity could not be increased by introducing electron-withdrawing, electron-releasing or lipophilic substituents. Only compounds containing fluorine at the 2 or 4 positions exhibited similar activity to the model.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aed40147a379c6c086ddf82186b8d82a https://doi.org/10.1016/0223-5234(94)90204-6 Zobrazit plný text záznamu