A Multicomponent Synthesis of 4H-Pyrido[1,2-a]pyrimidine-2-hydroxy-4-one Derivatives and Assessment of Their Antimicrobial Activity

Autor:	Poornima Devi, Vineeta Singh, Abha Bishnoi
Rok vydání:	2021
Předmět:	Pyrimidine biology 010405 organic chemistry Stereochemistry Klebsiella pneumoniae Organic Chemistry Antimicrobial medicine.disease_cause biology.organism_classification 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Staphylococcus aureus medicine Antibacterial activity Chromobacterium violaceum Escherichia coli Bacteria
Zdroj:	Russian Journal of Organic Chemistry. 57:265-271
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428021020184
Popis:	A highly efficient method for the multicomponent synthesis of substituted 4H-pyrido[1,2-a]pyrimidine-2-hydroxy-4-one derivatives, starting from 4H-pyrido[1,2-a]primidine-2-hydroxy-4-one, β-naphthol, and substituted aromatic aldehydes, in moderate to good yields has been developed. The structure of the pyridopyrimidine derivatives was established by spectral methods. In vitro antibacterial activity of the newly synthesized compounds was evaluated against highly pathogenic Gram-positive [Staphylococcus aureus (MTCC 96)] and Gram-negative [Pseudomonas aeruginosa (MTCC 424), Salmonella typhi (MTCC 537), Klebsiella pneumoniae (MTCC 424), Escherichia coli (MTCC 64) and Chromobacterium violaceum] bacteria.
Databáze:	OpenAIRE
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