ChemInform Abstract: Total Synthesis of (-)-Lasubine II by the Conjugate Addition and Intramolecular Acylation of an Amino Ester with an Acetylenic Sulfone

Autor:	Thomas G. Back, Michael D. Hamilton
Rok vydání:	2010
Předmět:	Acylation Addition reaction chemistry.chemical_compound Lasubine II Chemistry Intramolecular force Total synthesis Stereoselectivity General Medicine Medicinal chemistry Conjugate Sulfone
Zdroj:	ChemInform. 33
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200240211
Popis:	The conjugate addition of methyl (S)-(2-piperidyl)acetate (3) to 2-(3,4-dimethoxyphenyl)-1-(p-toluenesulfonyl)ethyne (4), followed by LDA-promoted intramolecular acylation, stereoselective reduction, and desulfonylation, afforded (−)-lasubine II.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aecb3e611b36dd8ce28e11a9a7ef104a https://doi.org/10.1002/chin.200240211 Zobrazit plný text záznamu Plný text