Intraocular pressure response to acetazolamide in patients with retinal detachment
| Autor: | W Ghouali, C Arndt, A Ducasse |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Intraocular pressure
medicine.medical_specialty Retinal pigment epithelium genetic structures business.industry Retinal detachment General Medicine Vitreous traction medicine.disease Fluid transport eye diseases Ophthalmology medicine.anatomical_structure Medicine In patient sense organs Epiretinal membrane business Acetazolamide medicine.drug |
| Zdroj: | Acta Ophthalmologica. 90 |
| ISSN: | 1755-375X |
| DOI: | 10.1111/j.1755-3768.2012.s062.x |
| Popis: | Purpose Besides the responsibility of vitreous traction, deficient photoreceptors adherence due to lower fluid transport of the retinal pigment epithelium (RPE) has been hypothezised to be involved in the occurrence of retinal detachment(RD). However this adherence remains difficult to evaluate in patients. Acetazolamide reduces aqueous secretion of the ciliairy body and stimulates fluid absorption by the RPE. Recording the intraocular pressure response to systemic acetazolamide could enable to indirectly evaluate the carbonic anhydrase activity of the RPE. Methods The response to intraveineous acetazolamide was evaluated on the first postoperative day in 30 patients undergoing either RD surgery (n=15) or epiretinal membrane peeling (n=15). Intraocular pressure was measured with a handheld Perkins tonometer in suppine position before (t-2 min) and after the administration of acetazolamide (t+2 min,t+6min ,t+10 min and t+30 min). The mean variation of the intraocular pressure was compared between the two groups. Results Consecutively to the intraveineous injection of acetazolamide, a reduction of the intraocular pressure was observed in both groups (both n=15). This reduction was significantly lower in the group of patients who underwent RD surgery. The observed difference remained significant until 10 minutes (p |
| Databáze: | OpenAIRE |
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