CD14+CD16+ monocytes play distinct role in Plasmodium vivax malaria (MPF3P.817)
| Autor: | Lis Antonelli, Fabiana Leoratti, Pedro Costa, Bruno Rocha, Suelen Diniz, Mauro Tada, Dhelio Pereira, Douglas Golenbock, Ricardo Gonçalves, Ricardo Gazzinelli |
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| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 192:132.17-132.17 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | During malaria, the Plasmodium triggers high levels of cytokines, which both help the immune response controlling the parasite and contribute to the symptoms observed during the diseases. Our data show that monocytes are the main source of cytokines upon P. vivax infection, suggesting their important role during disease. While it is recognized that monocytes are heterogeneous, the physiological relevance of this is not yet completely understood. The different monocyte subsets seem to reflect developmental stages with distinct roles. Our goal is to define the role of monocyte during P. vivax infection. Our data show that higher levels of cytokines, accompanied by increased frequencies of monocytes in P. vivax-infected patients. The infection triggers the expression of activation markers, adhesion molecules and chemokine receptors on monocytes. Moreover, these cells can be distinguished into three monocyte subsets based on the expression of CD14 and CD16. Each of these subsets display an distinct profile, suggesting that they distinctly act during P. vivax infection to induce inflammation, control the infection and modulate immune response. Importantly, CD14+CD16+ monocytes displayed higher phagocytic activity and killing potential than their other counterparts. Identification of mechanisms that regulate monocyte responses during malaria will provide important information on the development of therapeutic strategies that are targeted to modify their particular cell subsets |
| Databáze: | OpenAIRE |
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