| Popis: |
Post-thrombotic syndrome (PTS) is a complex and multifaceted disease with an incompletely understood pathophysiology, presenting significant clinical challenges. This review article examines the morphological aspects of PTS, including venous valve destruction, thrombus organization and fibrosis, and endothelial dysfunction, which contribute to the development and progression of the disease. A better understanding of these aspects is essential for the development of targeted therapies addressing the underlying mechanisms of PTS. Current treatment options, such as anticoagulation, compression therapy, thrombolysis, and pharmacological interventions, have shown variable success in managing PTS, necessitating novel therapeutic strategies. Emerging therapies, including targeted anticoagulation, advanced endovascular techniques, immunomodulation, gene therapy, and regenerative medicine, hold promise in addressing the pathophysiological mechanisms of PTS. Collaborative efforts among clinicians, researchers, and industry partners are vital for translating these findings into effective, patient-centered care for those affected by PTS, ultimately improving patient outcomes and transforming the management of this debilitating condition. |
