The mammalian circadian clock exhibits chronic tolerance to alcohol in vitro

Autor:	Rebecca A. Prosser, Jonathan H. Lindsay
Rok vydání:	2014
Předmět:	medicine.medical_specialty Ethanol Suprachiasmatic nucleus Circadian clock Glutamate receptor Biology chemistry.chemical_compound Endocrinology chemistry In vivo Internal medicine Zeitgeber medicine Premovement neuronal activity Circadian rhythm
Zdroj:	Proceedings of the 2014 Biomedical Sciences and Engineering Conference.
Popis:	Alcohol abuse leads to cognitive defects, depression, and sleep disturbances. The connection between sleep and circadian disruptions led us to investigate ethanol's effect on the circadian clock. We demonstrated that acute ethanol blocks photic phase shifts in vivo and glutamatergic phase shifts in vitro. Ethanol exposure can lead to acute, rapid and/or chronic tolerance. We determined that the suprachiasmatic nucleus (SCN) circadian clock exhibits acute (developing in
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aeb6770decb28f48a3c12f334deb41be https://doi.org/10.1109/bsec.2014.6867739 Zobrazit plný text záznamu