In Vitro and in Vivo Release of Salicylic Acid from Povidone/Polydimethylsiloxane Matrices

Autor:	Sanford Bolton, Ralph Tarantino, Dennis Adair
Rok vydání:	1990
Předmět:	Pharmacology Chromatography Polydimethylsiloxane Organic Chemistry technology industry and agriculture Pharmaceutical Science macromolecular substances In vitro chemistry.chemical_compound chemistry In vivo Drug Discovery Drug delivery Drug release Organic chemistry Salicylic acid
Zdroj:	Drug Development and Industrial Pharmacy. 16:1217-1231
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639049009114938
Popis:	Povidone (PVP)/Polydimethylsiloxane (PDMS) matrices were evaluated as drug delivery devices. PVP was utilized as a hydrophilic component to alter drug release. Salicylic acid was employed as a model drug substance.Discs were prepared by placing the blended ingredients into a mold and allowing PDMS to cross-link at room temperature. The experimental formulations were evaluated for salicylic release via in vitro and in vivo experiments. In vitro experiments were conducted by USP Method II. In vivo release was determined by monitoring salicylate depletion after subdermal implantation. In vitro and in vivo release rate of salicylic acid was found to be proportional to PVP concentration. All release rate curves displayed t1/2relationships for at least 75% of the total release period. Mouse survival was related to salicylic acid release rate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aeaa741c38b6354cab48089f3d5b6bc7 https://doi.org/10.3109/03639049009114938 Zobrazit plný text záznamu