Diagnostic utility of circulating plasma microRNA-101a in severity of coronary heart disease
| Autor: | Huimin Liu, Huai Yu, Ying-Feng Tu, Maoen Xu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Univariate analysis business.industry Blood lipids General Medicine Odds ratio 030204 cardiovascular system & hematology Logistic regression Coronary heart disease Correlation 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Biomarker (medicine) 030212 general & internal medicine business Cholesterol homeostasis |
| Zdroj: | Irish Journal of Medical Science (1971 -). 190:1391-1396 |
| ISSN: | 1863-4362 0021-1265 |
| DOI: | 10.1007/s11845-021-02512-7 |
| Popis: | For evaluating the severity of coronary heart disease (CHD), coronary arteriography may not be available everywhere due to technical limitations. MicroRNA-101a (miR-101a) associated with inflammation and cholesterol homeostasis. However, whether it related to presence and stratification of CHD is still unknown. We aim to evaluate the value of miR-101a in stratifying CHD patients. We enrolled 200 CHD patients and 100 controls, and 200 CHD patients were divided into two groups of low and high SYNTAX score (SYNTAX score ≤ 22 versus SYNTAX score ≥ 33). Intergroup comparisons of miR-101a level were compared among the controls and two groups of low and high SYNTAX score. Correlation between miR-101a and blood lipid profiles was analyzed. The logistic regression analysis were conducted to evaluate the risk factors of CHD. Relative level of miR-101a in the controls, SYNTAX score ≤ 22 and SYNTAX score ≥ 33 group were 4.61 (1.24–8.91), 3.28 (0.58–6.75) and 2.29 (1.04–3.62), respectively (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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