Neuregulin-1 is a chemoattractant and chemokinetic molecule for trunk neural crest cells

Autor:	Maria Elena de Bellard, Nora Zuhdi, Blanca Ortega, Joshua Herman, Lino Kim, Sothy Sao
Rok vydání:	2018
Předmět:	0301 basic medicine animal structures Morphogenesis Neural crest Embryo Cell migration Chemotaxis Biology Trunk Cell biology 03 medical and health sciences 030104 developmental biology Trunk neural crest cell migration embryonic structures biology.protein Neuregulin 1 Developmental Biology
Zdroj:	Developmental Dynamics. 247:888-902
ISSN:	1058-8388
DOI:	10.1002/dvdy.24625
Popis:	Background: Trunk neural crest cells migrate rapidly along characteristic pathways within the developing vertebrate embryo. Proper trunk neural crest cell migration is necessary for the morphogenesis of much of the peripheral nervous system, melanocytes, and the adrenal medulla. Numerous molecules help guide trunk neural crest cell migration throughout the early embryo. Results: Here, we show that the trophic factor NRG1 is a chemoattractant through in vitro chemotaxis assays and in vivo silencing via a DN-erbB receptor. Interestingly, we also observed changes in migratory responses consistent with a chemokinetic effect of NRG1 in trunk neural crest velocity. Conclusions: NRG1 is a trunk neural crest cell chemoattractant and chemokinetic molecule. This article is protected by copyright. All rights reserved.
Databáze:	OpenAIRE
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